Between 10-20% of the human breast cancers are considered Triple Negative Breast Cancer (TNBC), which means that the tumour cells do not express the receptors for estrogen, progesterone, and Her2. In practice, that means that anticancer drugs that target these receptors or hormone therapy will not be effective.
To study the dynamics and effect of possible drugs against TNBC, we engrafted the cell line MDA-Mb231, one of the most commonly used breast cancer cell lines, in zebrafish larvae.
1 Day Post Engraftment
2 Days Post Engraftment
4 Days Post Engraftment
Each representative image is derived from a pool of engrafted embryos (images are not from the same fish)